2021 Teréga Open Pau–Pyrénées – Singles

Ernests Gulbis was the defending champion but chose not to defend his title.

Radu Albot won the title after defeating Jiří Lehečka 6–2, 7–6(7–5) in the final.

Seeds
• # 🇪🇸 Feliciano López (quarterfinals)

• # Holger Rune (semifinals)

• # 🇫🇷 Gilles Simon (first round)

• # 🇦🇹 Dennis Novak (first round)

• # 🇸🇰 Norbert Gombos (quarterfinals)

• # 🇺🇸 Maxime Cressy (quarterfinals)

• # 🇲🇩 Radu Albot (champion)

• # 🇨🇿 Zdeněk Kolář (first round)