2021 William & Mary Tribe football team

The 2021 William & Mary Tribe football team represented the College of William & Mary as a member of the Colonial Athletic Association (CAA) in the 2021 NCAA Division I FCS football season. The Tribe, led by third-year head coach Mike London, played their home games at Zable Stadium.

CAA poll
In the CAA preseason poll released on July 27, 2021, the Tribe were predicted to finish in 11th place.

Preseason All-CAA team
Punt returner Bronson Yoder was selected to the preseason All-CAA Team, while Andrew Trainer (offensive line) and Will Kiely (defensive line) were selected as preseason honorable mention picks.