2022 Challenger La Manche – Singles

Ruben Bemelmans was the defending champion but lost in the quarterfinals to Zizou Bergs.

Benjamin Bonzi won the title after defeating Constant Lestienne 6–4, 2–6, 6–4 in the final.

Seeds
• # 🇫🇷 Benjamin Bonzi (champion)

• # 🇫🇷 Pierre-Hugues Herbert (quarterfinals)

• # 🇨🇿 Tomáš Macháč (first round)

• # 🇦🇹 Dennis Novak (second round)

• # 🇫🇷 Gilles Simon (second round)

• # 🇫🇷 Quentin Halys (second round)

• # 🇷🇺 Roman Safiullin (first round)

• # 🇫🇷 Lucas Pouille (first round, retired)