2022 Champaign–Urbana Challenger – Singles

Stefan Kozlov was the defending champion but lost in the first round to Prajnesh Gunneswaran.

Ben Shelton won the title after defeating Aleksandar Vukic 0–6, 6–3, 6–2 in the final.

Seeds
• # 🇺🇸 Denis Kudla (first round)

• # 🇺🇸 Steve Johnson (quarterfinals)

• # 🇺🇸 Christopher Eubanks (semifinals)

• # 🇺🇸 Ben Shelton (champion)

• # 🇺🇸 Stefan Kozlov (first round)

• # 🇦🇺 Aleksandar Vukic (final)

• # 🇺🇸 Aleksandar Kovacevic (semifinals)

• # 🇨🇳 Shang Juncheng (first round)