2022 Georgia's Rome Tennis Open – Singles

Irene Burillo Escorihuela was the defending champion but lost in the first round to Christina McHale.

Tatjana Maria won the title, defeating Alycia Parks in the final, 6–4, 4–6, 6–2.

Seeds
• # 🇲🇽 Renata Zarazúa (first round)

• # 🇧🇾 Olga Govortsova (first round)

• # 🇨🇳 Wang Xiyu (second round)

• # 🇨🇳 Yuan Yue (second round)

• # 🇺🇸 CoCo Vandeweghe (first round, retired)

• # Leonie Küng (first round)

• # 🇺🇸 Hailey Baptiste (second round)

• # 🇺🇸 Grace Min (withdrew)