2022 Hamburg Ladies & Gents Cup – Women's singles

Antonia Ružić was the defending champion but chose not to participate.

Rebeka Masarova won the title, defeating Ysaline Bonaventure in the final, 6–4, 6–3.

Seeds
• # 🇧🇪 Ysaline Bonaventure (final)

• # 🇺🇦 Kateryna Baindl (withdrew)

• # 🇮🇹 Lucrezia Stefanini (first round)

• # Despina Papamichail (second round)

• # Ekaterine Gorgodze (first round)

• # 🇪🇸 Rebeka Masarova (champion)

• # 🇩🇪 Nastasja Schunk (first round)

• # Anastasia Tikhonova (quarterfinals)