2022 LTP Charleston Pro Tennis – Singles

Claire Liu was the defending champion but chose not to participate.

Taylor Townsend won the title, defeating Wang Xiyu in the final, 6–3, 6–2.

Seeds
• # 🇷🇴 Irina Bara (quarterfinals)

• # 🇩🇪 Tatjana Maria (second round)

• # 🇺🇸 Katie Volynets (quarterfinals)

• # 🇺🇸 Hailey Baptiste (second round)

• # 🇨🇳 Wang Xiyu (final)

• # 🇺🇸 CoCo Vandeweghe (first round)

• # 🇮🇹 Lucrezia Stefanini (first round)

• # 🇵🇱 Katarzyna Kawa (first round)