2022 MLS expansion draft

The 2022 MLS Expansion Draft was a special draft for the Major League Soccer expansion team St. Louis City SC that was held on November 11, 2022. The list of exposed players was revealed on November 10, 2022. The picks were made on November 11, 2022, at 6:30 PM ET with St. Louis City SC selecting Nicholas Gioacchini, Indiana Vassilev, Jonathan Bell, John Nelson, and Jake LaCava.

Format
Teams who had players selected in the 2021 MLS Expansion Draft were exempt. These teams were Austin FC, Atlanta United FC, D.C. United, Los Angeles FC, and New York City FC. All other teams from the 2022 season were subject to the draft. These teams had 12 protection slots that they may apply to any draft eligible player on their senior, and supplemental rosters. Players who have not graduated from Generation Adidas, and homegrown players age 25 and under as of the end of the 2022 season were not eligible for the draft. Players with contracts expiring at the end of the season, designated players, and players with no-trade clauses were part of a team's roster and were eligible for the draft. In the case of players with no-trade clauses, a team must use one of their protection slots for that player. A team that had a player selected in the draft became exempt from any further picks in the draft. The expansion team, St. Louis City SC was given 5 picks for the draft.