2022 Mercer Tennis Classic – Singles

Madison Brengle was the defending champion and successfully defended her title, defeating Panna Udvardy in the final, 6–3, 6–1.

Seeds
• # 🇺🇸 Madison Brengle (champion)

• # 🇭🇺 Panna Udvardy (final)

• # 🇸🇪 Rebecca Peterson (withdrew)

• # 🇺🇸 Katie Volynets (semifinals)

• # 🇺🇸 Emma Navarro (quarterfinals)

• # 🇺🇸 Katrina Scott (first round)

• # 🇺🇸 Taylor Townsend (quarterfinals)

• # 🇦🇷 Nadia Podoroska (quarterfinals)