2021 Mercer Tennis Classic – Singles

Catherine Bellis was the defending champion but chose not to participate.

Madison Brengle won the title, defeating Zarina Diyas in the final, 6–4, 4–6, 6–4.

Seeds
• # 🇺🇸 Madison Brengle (champion)

• # 🇰🇿 Zarina Diyas (final)

• # 🇸🇰 Kristína Kučová (first round, retired)

• # 🇧🇷 Beatriz Haddad Maia (semifinals)

• # 🇲🇽 Renata Zarazúa (quarterfinals, retired)

• # 🇦🇺 Maddison Inglis (first round)

• # 🇨🇳 Wang Xiyu (semifinals)

• # 🇨🇦 Rebecca Marino (first round)