2022 Monterrey Challenger – Singles

Adrian Mannarino was the defending champion but chose not to defend his title.

Fernando Verdasco won the title after defeating Prajnesh Gunneswaran 4–6, 6–3, 7–6(7–3) in the final.

Seeds
• # 🇪🇸 Fernando Verdasco (champion)

• # 🇬🇧 Jay Clarke (second round)

• # Jason Jung (quarterfinals)

• # 🇩🇪 Cedrik-Marcel Stebe (first round)

• # 🇦🇷 Juan Pablo Ficovich (second round)

• # 🇫🇷 Maxime Janvier (first round)

• # 🇮🇳 Prajnesh Gunneswaran (final)

• # 🇫🇷 Geoffrey Blancaneaux (quarterfinals)