2022 Odlum Brown Vancouver Open – Men's singles

Ričardas Berankis was the defending champion but lost in the quarterfinals to Arthur Rinderknech.

Constant Lestienne won the title after defeating Rinderknech 6–0, 4–6, 6–3 in the final.

Seeds
• # 🇯🇵 Yoshihito Nishioka (first round, retired)

• # 🇨🇿 Jiří Veselý (second round)

• # 🇫🇷 Arthur Rinderknech (final)

• # 🇸🇪 Mikael Ymer (quarterfinals)

• # 🇫🇷 Constant Lestienne (champion)

• # 🇱🇹 Ričardas Berankis (quarterfinals)

• # Nicolás Jarry (first round)

• # Marc-Andrea Hüsler (second round)