2022 Open de Oeiras – Singles

Gastão Elias was the defending champion and successfully defended his title, defeating Nino Serdarušić 6–3, 6–4 in the final.

Seeds
• # 🇫🇷 Benoît Paire (withdrew)

• # 🇮🇹 Gianluca Mager (first round, retired)

• # 🇮🇹 Stefano Travaglia (second round)

• # 🇧🇷 Thiago Monteiro (quarterfinals)

• # 🇨🇿 Zdeněk Kolář (second round)

• # Nuno Borges (semifinals)

• # 🇨🇿 Vít Kopřiva (quarterfinals)

• # 🇮🇹 Alessandro Giannessi (semifinals)