2022 Open de Oeiras II – Singles

Gastão Elias was the two-time defending champion and successfully defended his title, defeating Alessandro Giannessi 7–6(7–4), 6–1 in the final.

Seeds
• # 🇧🇷 Thiago Monteiro (first round)

• # 🇨🇿 Zdeněk Kolář (semifinals)

• # Nuno Borges (second round)

• # 🇦🇺 Christopher O'Connell (quarterfinals)

• # 🇮🇹 Alessandro Giannessi (final)

• # 🇰🇿 Dmitry Popko (second round)

• # 🇸🇰 Jozef Kovalík (semifinals)

• # 🇧🇬 Dimitar Kuzmanov (quarterfinals)