2022 Orlando Open – Singles

Christopher Eubanks was the defending champion but lost in the quarterfinals to Wu Yibing.

Wu won the title after Jason Kubler retired in the middle of the third set with the score 6–7(5–7), 6–4, 3–1 in favor of Wu.

Seeds
• # 🇺🇸 J. J. Wolf (semifinals)

• # 🇪🇨 Emilio Gómez (semifinals)

• # 🇺🇸 Christopher Eubanks (quarterfinals)

• # 🇦🇺 Jason Kubler (final, retired)

• # 🇺🇸 Michael Mmoh (first round)

• # 🇹🇷 Altuğ Çelikbilek (first round)

• # 🇺🇸 Bjorn Fratangelo (first round)

• # 🇦🇺 Rinky Hijikata (second round)