2022 Slovak Open – Men's singles

Tallon Griekspoor was the defending champion but chose not to defend his title.

Márton Fucsovics won the title after defeating Fábián Marozsán 6–2, 6–4 in the final.

Seeds
• # 🇨🇳 Zhang Zhizhen (first round)

• # 🇭🇺 Márton Fucsovics (champion)

• # 🇸🇰 Norbert Gombos (quarterfinals)

• # 🇨🇿 Tomáš Macháč (semifinals)

• # Tim van Rijthoven (quarterfinals)

• # 🇦🇹 Jurij Rodionov (second round, retired)

• # Jelle Sels (first round)

• # 🇸🇰 Jozef Kovalík (second round)