2022 Slovak Open – Women's singles

Andreea Mitu was the defending champion but chose not to participate.

Ana Konjuh won the title, defeating Nigina Abduraimova in the final, 2–6, 6–0, 7–6(7–2).

Seeds
• # 🇸🇰 Anna Karolína Schmiedlová (quarterfinals)

• # 🇺🇦 Daria Snigur (quarterfinals)

• # 🇩🇪 Eva Lys (first round, retired)

• # Ana Konjuh (champion)

• # 🇸🇰 Viktória Kužmová (first round)

• # 🇷🇴 Jaqueline Cristian (second round)

• # 🇷🇴 Alexandra Cadanțu-Ignatik (first round, retired)

• # 🇺🇿 Nigina Abduraimova (final)