2022 Sparta Prague Open – Singles

Dalibor Svrčina was the defending champion but lost in the final to Sebastian Ofner.

Ofner won the title after defeating Svrčina 6–0, 6–4 in the final which was characterized by bad rainy weather to the point it was interrupted on 4–0 in favor of Ofner and concluded on indoor hard courts.

Seeds
• # 🇩🇪 Daniel Altmaier (second round)

• # 🇩🇪 Mats Moraing (second round)

• # Tseng Chun-hsin (semifinals)

• # 🇫🇷 Lucas Pouille (first round)

• # 🇦🇹 Dennis Novak (second round)

• # 🇨🇿 Tomáš Macháč (semifinals, withdrew)

• # 🇨🇿 Vít Kopřiva (withdrew)

• # 🇦🇹 Jurij Rodionov (second round)

• # 🇰🇿 Dmitry Popko (first round)