2022 U.S. Pro Women's Clay Court Championships – Singles

Barbora Krejčíková was the defending champion but chose not to participate.

Katie Volynets won the title, defeating Wang Xiyu in the final, 6–4, 6–3.

Seeds
• # 🇨🇳 Wang Xinyu (first round)

• # 🇦🇺 Astra Sharma (withdrew)

• # 🇷🇴 Irina Bara (semifinals)

• # 🇺🇸 Hailey Baptiste (first round)

• # 🇨🇳 Wang Xiyu (final)

• # 🇺🇸 Alycia Parks (second round)

• # Anastasia Gasanova (first round)

• # 🇺🇸 Katie Volynets (champion)