2022 UniCredit Czech Open – Singles

Federico Coria was the defending champion but lost in the first round to Dalibor Svrčina.

Vít Kopřiva won the title after defeating Svrčina 6–2, 6–2 in the final.

Seeds
• # 🇦🇷 Federico Coria (first round)

• # 🇨🇿 Jiří Veselý (withdrew)

• # 🇨🇿 Jiří Lehečka (withdrew)

• # 🇪🇸 Pablo Andújar (second round)

• # 🇸🇰 Norbert Gombos (first round)

• # 🇸🇪 Elias Ymer (second round)

• # 🇸🇰 Andrej Martin (first round)

• # 🇨🇿 Zdeněk Kolář (first round)