2023 Mexico City Open – Singles

Marc-Andrea Hüsler was the defending champion but lost in the second round to Federico Gaio.

Dominik Koepfer won the title after defeating Thiago Agustín Tirante 2–6, 6–4, 6–2 in the final.

Seeds
• # Marc-Andrea Hüsler (second round)

• # 🇨🇴 Daniel Elahi Galán (second round)

• # 🇦🇷 Facundo Bagnis (first round)

• # 🇦🇺 James Duckworth (second round)

• # 🇩🇪 Yannick Hanfmann (first round)

• # Alejandro Tabilo (second round)

• # 🇧🇷 Felipe Meligeni Alves (second round)

• # 🇮🇹 Luciano Darderi (first round)