2024 São Léo Open – Singles

Juan Pablo Varillas was the defending champion but lost in the semifinals to Enzo Couacaud.

Daniel Vallejo won the title after defeating Couacaud 6–3, 6–2 in the final.

Seeds
• # 🇵🇪 Juan Pablo Varillas (semifinals)

• # 🇧🇷 Thiago Monteiro (first round)

• # 🇦🇷 Camilo Ugo Carabelli (quarterfinals)

• # 🇧🇷 Felipe Meligeni Alves (semifinals)

• # 🇦🇷 Román Andrés Burruchaga (withdrew)

• # 🇦🇷 Genaro Alberto Olivieri (second round)

• # 🇫🇷 Geoffrey Blancaneaux (first round)

• # Gonçalo Oliveira (quarterfinals)

• # 🇧🇷 Gustavo Heide (withdrew)