Benzhydryl compounds

The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane (which is two benzene rings connected by a single methane), with any number of attached substituents, including bridges. This group typically excludes compounds in which either benzene is fused to another ring (bicyclic, tricyclic, polycyclic) or includes a heteroatom, or where the methane connects to three or four benzenes.

The benzhydryl radical can be abbreviated or Bzh.

Alcohols

 * Acyclic: pridinol
 * Pyrolidino: diphenylprolinol
 * 2-Piperidine: pipradrol
 * 4-Piperidine: terfenadine, fexofenadine
 * Benzilic ester: QNB, JB-336, JB-318, benactyzine

Alkenes

 * Tricycle: amitriptyline, melitracen, cyclobenzaprine, tianeptine, amineptine, clopenthixol, chlorprothixene, flupentixol, thiothixene, zuclopenthixol
 * Tricyclic and piperidine: pimethixene, cyproheptadine
 * Acyclic: gilutensin

Alkyl(amine)s

 * Acyclic: (3-phenylpropylamine), tolpropamine, tolterodine
 * Piperidine: desoxypipradrol, budipine
 * N-alkyl-4-piperidinol: penfluridol
 * N-arylalkyl-piperidine: pimozide
 * Tetrahydronaphthalene: tametraline (4-phenylaminotetralin), sertraline
 * Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline (see doxanthrine and dinoxyline)
 * Pyrroloisoquinoline: JNJ-7925476
 * Indanamine: Lu 19-005
 * Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine (see MPTP)
 * Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
 * Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
 * Piperazine: amperozide
 * Triazaspiro: fluspirilene

Alkoxy compounds

 * Acyclic (3 °C): diphenhydramine (c.f deramciclane), orphenadrine, p-methyldiphenhydramine
 * Acyclic (4 °C): moxastine, Clemastine, embramine,
 * Piperazine: GBR-12935, GBR 12909, DBL-583
 * Tropine: benztropine, deptropine, etybenzatropine, difluoropine
 * Piperidine: diphenylpyraline
 * Phthalane: talopram, citalopram
 * Octahedral: nefopam
 * Benzdihydropyran: A-68930 (isochromene)

Amines

 * Piperazine: cyclizine, clocinizine, hydroxyzine, meclozine, cetirizine, dotarizine, cinnarizine
 * Benzazepine: mianserin
 * Tetracyclic: dizocilpine

Other

 * Aromatic alkoxy: bifemelane, phenyltoloxamine
 * Keto: phenadoxone, methadone, dipipanone, etc.
 * Amido: dextromoramide
 * Imino: benzodiazepine, GYKI-52895
 * Sulfinyl: modafinil, adrafinil
 * Pituxate gem-diphenylcyclopropane

Heteroaromatic
These species are not strictly benzhydryl-containing but are analogous.

Heteroaromatic rings

 * Alkene: thiambutene, loratadine
 * Alkylamine: A-86929, amfonelic acid

Benzenes linked by a non-carbon atom

 * Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
 * Indolic nitrogen: sertindole
 * Oxygen: loxapine, asenapine, tyrima

Benzene and heterocycle linked through a non-carbon

 * Olanzapine