Big Mouth season 5

The fifth season of Big Mouth was released on Netflix on November 5, 2021.

Main

 * Nick Kroll as Nick Birch, Maurice the Hormone Monster, Coach Steve Steve, Lola Skumpy, Mila Jansen, Lotte Jansen and Bad Mitten
 * Kroll also appears as himself in live-action in the season five finale, as the person in charge of Human Resources.
 * John Mulaney as Andrew Glouberman and Detective Florez
 * Jessi Klein as Jessi Glaser
 * Jason Mantzoukas as Jay Bilzerian
 * Ayo Edebiri as Missy Foreman-Greenwald
 * Fred Armisen as Elliot Birch
 * Maya Rudolph as Connie the Hormone Monstress and Diane Birch
 * Jordan Peele as Cyrus Forman-Greenwald, Featuring Ludacris and Ghost of Duke Ellington

Recurring
• Andrew Rannells as Matthew MacDell

• Pamela Adlon as Sonya

• Brandon Kyle Goodman as Walter

• Keke Palmer as Rochelle

• Ali Wong as Ali

• David Thewlis as Lionel St. Swithens

• Thandwie Newton as Mona

• Joe Wengert as Caleb, Lump Humpman

• June Diane Raphael as Devin LeSeven

• Jak Knight as DeVon

• Joel Kim Booster as Charles Lu

• Neil Casey as Lars and Detective Dumont

• Richard Kind as Marty Glouberman

• Paula Pell as Barbara Glouberman

• Chelsea Peretti as Monica Foreman-Greenwald

• Natasha Lyonne as Suzette

• Nathan Fillion as Himself

• Seth Morris as Greg Glaser

• Chloe Fineman as Leah Birch

• Jon Daly as Judd Birch

• Fran Gillespie as Samira

• Mark Duplass as Val Bilzerian

• Zachary Quinto as Aiden

Guest
• Kumail Nanjiani as Himself

• Maria Bamford as Tito

• Jessica Chaffin - Shannon Glaser

• Andy Daly as Dr. Wendy Ingle

• Gina Rodriguez as Gina Alvarez

• Aidy Bryant as Emmy

• Natasha Lyonne - Suzette

• Hugh Jackman as Himself

• Adam Scott as Dylan Keating

• Quinta Brunson as Quinta Foreman

• Lena Waithe as Lena Foreman

• Kristen Wiig as Jessi's Vagina

• Jemaine Clement as Simon Sex

• Jean Smart as Depression Kitty

• Rosa Salazar as Miss Benitez

• Kristen Schaal as Bernie Sanders

• Gary Cole as Edward MacDell

• Julie White as Kimberly MacDell

Critical response
On Rotten Tomatoes, the fifth season has an approval rating of 100% based on 5 reviews. On Metacritic, it has a score of 5 out of 0 for the fifth season, based on 1 critic, indicating "universal acclaim".