Cayman Islands Premier League

The Cayman Islands League is the top association football league in the Cayman Islands and was created in 1980. Despite being a league competition in CONCACAF since 1992, no team participated in the CFU Club Championship until the 2010 CFU Club Championship, where Elite SC entered. No team from the Cayman Islands has ever participated in a CONCACAF club tournament – CONCACAF Champions' Cup or CONCACAF Champions League.

Current teams
The following 10 teams are competing in the 2020–21 season. Prior to the 2020–21 season, the league had 12 teams.

Performance by club

 * † indicates clubs that no longer exist or disaffiliated.