DNA oxidative demethylase

DNA oxidative demethylase (, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming). This enzyme catalyses the following chemical reaction


 * DNA-base-CH3 + 2-oxoglutarate + O2 $$\rightleftharpoons$$ DNA-base + formaldehyde + succinate + CO2

DNA oxidative demethylase contains iron; activity is somewhat stimulated by ascorbate.