Dimethylmalate dehydrogenase

In enzymology, a dimethylmalate dehydrogenase is an enzyme that catalyzes the chemical reaction


 * (R)-3,3-dimethylmalate + NAD+ $$\rightleftharpoons$$ 3-methyl-2-oxobutanoate + CO2 + NADH

Thus, the two substrates of this enzyme are (R)-3,3-dimethylmalate and NAD+, whereas its 3 products are 3-methyl-2-oxobutanoate, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating). This enzyme is also called beta,beta-dimethylmalate dehydrogenase. This enzyme participates in pantothenate and coa biosynthesis. It has 5 cofactors: ammonia, manganese, cobalt, potassium, and NH4+.