Ent-kaurenoic acid oxidase

Ent-kaurenoic acid oxidase is an enzyme with systematic name ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating). This enzyme catalyses the following chemical reaction


 * ent-kaur-16-en-19-oate + 3 NADPH + 3 H+ + 3 O2 $$\rightleftharpoons$$ gibberellin A12 + 3 NADP+ + 4 H2O (overall reaction)
 * (1a) ent-kaur-16-en-19-oate + NADPH + H+ + O2 $$\rightleftharpoons$$ ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
 * (1b) ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + H+ + O2 $$\rightleftharpoons$$ gibberellin A12 aldehyde + NADP+ + 2 H2O
 * (1c) gibberellin A12 aldehyde + NADPH + H+ + O2 $$\rightleftharpoons$$ gibberellin A12 + NADP+ + H2O

Ent-kaurenoic acid oxidase requires cytochrome P450.