List of Detroit Tigers first-round draft picks

The Detroit Tigers are a Major League Baseball (MLB) franchise based in Detroit, Michigan. They play in the American League Central division. Since the institution of MLB's Rule 4 Draft, the Tigers have selected 66 players in the first round. Officially known as the "First-Year Player Draft", the Rule 4 Draft is MLB's primary mechanism for assigning players from high schools, colleges, and other amateur clubs to its franchises. The draft order is determined based on the previous season's standings, with the team possessing the worst record receiving the first pick. In addition, teams which lost free agents in the previous off-season may be awarded compensatory or supplementary picks.

Of the 66 players picked in the first round by Detroit, 32 have been pitchers, the most of any position; 25 of these were right-handed, while five were left-handed. Thirteen outfielders were selected, while five shortstops, five catchers, four third basemen, three first basemen, and two second baseman were taken as well. One additional player, Lance Parrish (1974), was drafted as an infielder but ultimately spent the majority of his Major League career at catcher. Thirteen of the players came from high schools or universities in the state of California, followed by Texas with ten players. The Tigers have also drafted five players from their home state of Michigan.

Two of the Tigers' first-round picks have won championships with the franchise. Parrish and Kirk Gibson (1978) won a World Series title on the 1984 championship team. Justin Verlander (2004) is the only first-round pick of the Tigers to win the Rookie of the Year Award, taking the honor in 2006. Two Tigers first-round picks have won the Cy Young Award, both in the American League; Verlander won the award in 2011 with the Tigers and 2007 pick Rick Porcello won in 2016 with the Boston Red Sox. None of their first-round picks have been elected to the Baseball Hall of Fame. Justin Verlander became the first player who was drafted in the 1st round of the draft to win the Most Valuable Player award while with the Tigers in the 2011 season. Gibson won the MVP award in his first year with the Los Angeles Dodgers in 1988.

The Tigers have made ten selections in the supplemental round of the draft and have made the first overall selection three times (1997, 2018, and 2020). They have also had eight compensatory picks since the institution of the First-Year Player Draft in 1965. These additional picks are provided when a team loses a particularly valuable free agent in the previous off-season, or, more recently, if a team fails to sign a draft pick from the previous year. The Tigers failed to sign their 1966 first-round pick, Rick Konik, but they received no compensatory pick.