List of St. Louis Cardinals first-round draft picks

The St. Louis Cardinals are a Major League Baseball (MLB) franchise based in St. Louis, Missouri. They play in the National League Central division. Since the institution of MLB's Rule 4 Draft, the Cardinals have selected 77 players in the first round. Officially known as the "First-Year Player Draft", the Rule 4 Draft is MLB's primary mechanism for assigning amateur baseball players from high schools, colleges, and other amateur baseball clubs to its teams. The draft order is determined based on the previous season's standings, with the team possessing the worst record receiving the first pick. In addition, teams which lost free agents in the previous off-season may be awarded compensatory or supplementary picks.

Of the 77 players picked in the first round by St. Louis, 39 have been pitchers, the most of any position; 30 of them were right-handed, while nine were left-handed. Eight outfielders, ten third basemen, six shortstops, six first basemen, five catchers, and two second basemen were taken as well. The team also drafted one player, Leron Lee (1966), who played as an infielder. 16 of the players came from high schools or universities in the state of California, and Texas and Arizona follow with seven and six players. The Cardinals have not drafted any players from their home state of Missouri.

Three of the Cardinals' draft picks have won World Series rings with the team. Braden Looper (1996) and Chris Duncan (1999) were both members of the major league roster when the Cardinals won the 2006 World Series. Lance Lynn was with the 2011 World Series winners. None of the Cardinals' first-round picks have won the Cy Young Award. Todd Worrell (1982) is the only first-round pick of the Cardinals to earn the MLB Rookie of the Year award with the team, winning it in 1986. The Cardinals have never held the first overall pick in the draft, and have only held a top five pick three times. The highest pick the Cardinals have held was the third overall pick, which they used on Looper in 1996.

The Cardinals have made 18 selections in the supplemental round of the draft and 27 compensatory picks since the institution of the First-Year Player Draft in 1965. These additional picks are provided when a team loses a particularly valuable free agent in the previous off-season, or, more recently, if a team fails to sign a draft pick from the previous year. As the Cardinals have signed all of their first-round picks, they have never been awarded a supplementary pick under this provision.