List of investigational anxiolytics

This is a list of investigational anxiolytics, or anxiolytics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Generalized anxiety disorder

 * Riluzole sublingual (BHV-0223) – undefined mechanism of action
 * TGFK08AA – 5-HT1A receptor modulator
 * TGW00AA (FKW00GA) – 5-HT1A receptor agonist, 5-HT2A receptor antagonist

Panic disorder

 * Darigabat (PF-06372865) – GABAA receptor positive allosteric modulator
 * JNJ-61393215 – orexin OX1 receptor antagonist

Post-traumatic stress disorder

 * 7-Oxoprasterone (7-keto-DHEA; HBL-9001) – "immunomodulator" / undefined mechanism of action
 * BNC-210 (IW-2143) – "GABA modulator" / undefined mechanism of action
 * Brexpiprazole (Lu AF41156, OPC-34712; Rexulti) – atypical antipsychotic / 5-HT1A, D2 and D3 receptor partial agonist and 5-HT2A, 5-HT2B, 5-HT7, α1-adrenergic, α2-adrenergic, and H1 receptor antagonist
 * Iloperidone (HP-873, ILO-522; Fanapt, Fiapta, Zomaril) – atypical antipsychotic / 5-HT2A, 5-HT6, 5-HT7, D2, D3, D4, and α1-adrenergic receptor antagonist
 * MDMA (Midomafetamine, 3,4-methylenedioxymethamphetamine, "ecstasy") – serotonin–norepinephrine–dopamine releasing agent and 5-HT1 and 5-HT2 receptor agonist – specifically under development as an aid to psychotherapy for post-traumatic stress disorder
 * NBTX-001 (Xenon) – NMDA receptor antagonist
 * Pomaglumetad methionil (DB-103, LY-2140023) – mGluR2 and mGluR3 agonist
 * Tianeptine oxalate/naloxone (TNX-601) – atypical μ-opioid receptor agonist

Social anxiety disorder

 * Fasedienol (Aloradine; PH94B; 4-androstadienol) – vomeropherine / neurosteroid
 * JNJ-42165279 – FAAH inhibitor
 * TGW00AA (FKW00GA) – 5-HT1A receptor agonist, 5-HT2A receptor antagonist

Others/unspecified

 * AVN-101 – 5-HT6 receptor antagonist
 * BNC-210 (IW-2143) – "GABA modulator" / undefined mechanism of action / α7 subunit-containing nicotinic acetylcholine receptor antagonist
 * Deuterated etifoxine (GRX-917) – translocator protein (TSPO) agonist and GABAA receptor positive allosteric modulator
 * JNJ-42165279 – FAAH inhibitor
 * JNJ-61393215 – orexin OX1 receptor antagonist
 * MP-20X – CB1 and 5-HT1A receptor modulator
 * SRX-246 – vasopressin V1A receptor antagonist