List of prime ministers of São Tomé and Príncipe

This article lists the prime ministers of São Tomé and Príncipe, an island country in the Gulf of Guinea off the western equatorial coast of Central Africa, since the establishment of the office of prime minister of Portuguese São Tomé and Príncipe in 1974. Leonel Mário d'Alva was the first person to hold the office, taking effect on 21 December 1974. The incumbent is Patrice Trovoada, having taken office on 11 November 2022.

List of officeholders
{{legend||Movement for the Liberation of São Tomé and Príncipe – Social Democratic Party (MLSTP–PSD)|border=1px solid #aaa}} {{legend||Democratic Convergence Party (PCD)|border=1px solid #AAAAAA}} {{legend||Independent Democratic Action (ADI)|border=1px solid #aaa}} {{legend||Force for Change Democratic Movement – Liberal Party (MDFM–PL)|border=1px solid #aaa}} {{Legend||Union of Democrats for Citizenship and Development (UDD)|border=1px solid #aaa}}
 * Political parties