Los Premios 40 Principales 2010

Best Song

 * Alejandro Sanz (featuring Alicia Keys) — "Looking for Paradise"
 * Maldita Nerea — "Cosas que Suenan a..."
 * Robert Ramírez — "Sick of Love"
 * Estopa (featuring Rosario) — "El Run Run"
 * Pereza — "Lady Madrid"

Best Video

 * Alejandro Sanz — "Nuestro Amor Será Leyenda"
 * Dani Martín — "16 Añitos"
 * Carlos Jean — "Ay Haití"
 * Miguel Bosé — "Estuve A Punto De"
 * Maldita Nerea — "El Secreto de Las Tortugas"

Best Album

 * Miguel Bosé — Cardio
 * Alejandro Sanz — Paraíso Express
 * David Bisbal — Sin Mirar Atrás
 * Estopa — X Anniversarium
 * El Canto del Loco — Radio La Colifata presenta: El Canto del Loco

Best Solo

 * Melendi
 * Alejandro Sanz
 * El Pescao
 * Dani Martín
 * Enrique Iglesias

Group

 * Despistaos
 * Dover
 * Pignoise
 * Taxi
 * Maldita Nerea

Best New Act

 * Maldita Nerea
 * Pol 3.14
 * Funambulista
 * Preciados
 * Robert Ramírez

Best Tour

 * David Bisbal — Sin Mirar Atrás Tour
 * Miguel Bosé — Cardio Tour
 * Alejandro Sanz — Paraíso Express Tour
 * Maldita Nerea — El Secreto de Las Tortugas Tour
 * Pignoise — Año Zero Tour

Best Argentine Act

 * Miranda!
 * Teen Angels
 * Dante
 * Diego Torres
 * Emmanuel Horvilleur

Best Chilean Act

 * Koko
 * Mendez
 * Zaturno
 * Chico Trujillo
 * Croni K

Best Colombian Act

 * Dragon & Caballero
 * J. Balvin
 * Sebastian Yepes
 * Santiago Cruz
 * Don Tetto
 * Kio Dj

Best Costa Rican Act

 * Fuerza Dread
 * Percance
 * Escats
 * 4/ 24
 * Alonso Solis

Best Ecuadorian Act

 * Caalu
 * Norca
 * Tercer Mundo
 * Fausto Miño
 * Daniel Betancourt

Best Guatemalan Act

 * Francis Dávila
 * Malacates Trebol Shop
 * Duo Sway
 * El Clubo
 * Viento en Contra

Best Mexican Act

 * Alejandro Fernández
 * Camila
 * Belanova
 * Panteon Rococo
 * Moenia

Best Panamanian Act

 * Manuel Araúz
 * Iván Barrios
 * Margarita Henríquez
 * Comando Tiburón
 * Jhonny D

Best Latin Song

 * Shakira — "Waka Waka (Esto es África)"
 * Camila — "Mientes"
 * Diego Torres — "Guapa"
 * Juanes — "Yerbatero"
 * Paulina Rubio — "Ni Rosas Ni Juguetes"

Best Latin Act

 * Shakira
 * Juanes
 * Wisin & Yandel
 * Camila
 * Pitbull

Best International Song

 * David Guetta (featuring Akon) — "Sexy Bitch"
 * Kesha — "Tik Tok"
 * Lady Gaga — "Bad Romance"
 * Edward Maya (featuring Vika Jigulina) — "Stereo Love"
 * Taio Cruz — "Break Your Heart"

Best International Act

 * David Guetta
 * Lady Gaga
 * Kesha
 * Kylie Minogue
 * Rihanna

Lifetime Achievement Award

 * Cher

Presenters

 * Leonor Watling — presented Best Group
 * Mar Montoro — introduced Edward Maya (featuring Vika Jigulina)
 * Ana María Polvorosa and Pepa Rus — presented Best Costa Rican Act and Best International Act
 * José Motá — presented Best Chilean Act
 * Félix Gómez and Inma Cuesta — presented Best Tour
 * Ricky Martin — presented
 * La Mala Rodríguez — presented Best Colombian Act
 * Vanesa Sáez — Best Argentine Act
 * Ana Fernández and Luis Fernández — presented Best International Song
 * Fdez & Fdez — presented Best Ecuadorian Act
 * Tony Aguilar — introduced Dani Martín
 * Melanie Olivares and Vanessa Romero — presented Best Panamanian Act
 * Miren Ibarguren and Canco Rodríguez — presented Best Latin Song and Best Guatemalan Act
 * Mar Saura and Arturo Valls — presented Best Mexican Act
 * Álex Martínez and Úrsula Corberó — presented Best Video
 * Mario Casas and María Valverde — presented Best New Act
 * Sara Carbonero and José Ramón de la Morena — presented Best Latin Act and Best Solo
 * Alicia Sanz and Aleix Espargaró — presented Best Album
 * Angie Cepeda and Carlos Baute — presented Best Song