Matriptase

Matriptases are an enzyme family. This enzyme cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position

This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. It belongs to proteases of PA superfamily.

Human matriptases

 * ST14, also known as matriptase
 * TMPRSS6, also known as matriptase 2