Methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase

In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase is an enzyme that catalyzes the chemical reaction


 * methanol + 5-hydroxybenzimidazolylcobamide $$\rightleftharpoons$$ Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O

Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H2O.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.