Monocyclic monoterpene ketone monooxygenase

Monocyclic monoterpene ketone monooxygenase (, 1-hydroxy-2-oxolimonene 1,2-monooxygenase, dihydrocarvone 1,2-monooxygenase, MMKMO) is an enzyme with systematic name (-)-menthone,NADPH:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction


 * (1) (-)-menthone + NADPH + H+ + O2 $$\rightleftharpoons$$ (4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP+ + H2O
 * (2) dihydrocarvone + NADPH + H+ + O2 $$\rightleftharpoons$$ 4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O
 * (3) (iso)-dihydrocarvone + NADPH + H+ + O2 $$\rightleftharpoons$$ 6-isopropenyl-3-methyloxepan-2-one + NADP+ + H2O
 * (4a) 1-hydroxymenth-8-en-2-one + NADPH + H+ + O2 $$\rightleftharpoons$$ 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O
 * (4b) 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one $$\rightleftharpoons$$ 3-isopropenyl-6-oxoheptanoate (spontaneous)

Monocyclic monoterpene ketone monooxygenase is a flavoprotein (FAD).