PEA15

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.

Interactions
PEA15 has been shown to interact with:
 * Caspase 8,
 * FADD, and
 * MAPK1,
 * Phospholipase D1, and
 * RPS6KA3.