Talk:Adenomatous polyposis coli

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Some text in this article was originally taken from http://ghr.nlm.nih.gov/gene=apc (public domain)

Mischaracterization of effect of most common mutation
The article states: "The most common mutation in colon cancer is inactivation of APC. In absence of APC inactivating mutations," --Anotherbrian (talk) 18:32, 3 January 2021 (UTC)

As written the article suggests that the gene is inactive. Instead, proteins continue to synthesize but do not properly full fill their role. Example is SW480 colon cancer cell line which has truncated apc proteins. The gene is not inactivated. Also see for example Latchford's "APC mutations in FAP-associated desmoid tumours are non-random but not ‘just right’" Here a second somatic mutation occurs to apc (where the indivudal has an apc germline mutation). apc proteins continue to be produced but beta catenin destructor complex doesn't work. This area needs to be rewritten in the wiki article.

Rename according to the convention
Is there any reason not to move this article to adenomatosis polyposis coli? —Michael Z. 2006-12-14 20:56 Z 

It's strange but searching for adenomatosis polyposis coli and adenomatous polyposis coli in any protein or gene database (e.g. ebi.ac.uk or uniprot) gives out different protein lengths. Could anyone clarify if these two are profoundly different or they are still members of the same family? 79.72.181.217 (talk) 00:35, 11 January 2009 (UTC)
 * Some of the entries are fragments reporting the sequence of a mutation. The full length protein is about 2843 residues, varying a bit by species.96.54.53.165 (talk) 07:51, 22 October 2009 (UTC)
 * By the way, the structure used in the image is a tiny N-terminal fragment. The full protein is predicted to be an armadillo repeat from sequence data.  None of the PDB structures cited include more than a small fragment of the complete protein.96.54.53.165 (talk) 08:06, 22 October 2009 (UTC)

APC is more than a gene
The title of this article, "APC (gene)", is inappropriate. True, there is a gene that encodes for APC. However, the protein product of this gene is of the utmost importance in human biology. My point is merely semantic; I'm advocating for the renaming of this article. The suggestion (spelling out the words comprising the APC acronym) of the commenter above would suffice. -- Ante lan  talk  22:49, 19 March 2007 (UTC)
 * Wikiversity has some articles about genes and some articles about proteins. For example, there is both TP53 and p53. Sometimes if a gene/protein is known by an abbreviation, "(gene)" might get added to the name of the page even if the page includes information for both the gene and the protein. This might have been done in this case because APC is such a common three letter abbreviation. --JWSchmidt 23:01, 19 March 2007 (UTC)
 * I've set up a redirect from the spelled-out word to this article, which is probably sufficient. Ante  lan  talk  01:06, 22 March 2007 (UTC)
 * Is it Adenomatous polyposis coli or Adenomatosis polyposis coli? I've always seen the former, and it pulls more hits in GenBank. If you search PubMed with the term 'adenomatosis', it obligingly translates it to 'adenomatous'.96.54.53.165 (talk) 07:56, 22 October 2009 (UTC)

Merger proposal
I propose marging APC (protein) to this article. --Brewcrewer (talk) 22:38, 28 November 2007 (UTC)

The gene article makes a completely different point and cannot be merged wihtout loosing its intention. Folding uu 00:37, 2 December 2007 (UTC)

I support merging the two articles under the name APC (gene/protein), because 1) unlike p53 and TP53, the gene and its protein product share a name; 2) I had to read the APC (gene) article to find out what the protein product actually does; and 3) the information in the APC (protein) is not full or complete enough for a separate article--it would do very well as a section on known mutations of this gene/protein. Tchussle (talk) 19:41, 29 September 2009 (UTC)


 * I too agree with the merge proposal... Cheers, AndrewGNF (talk) 21:43, 29 September 2009 (UTC)

I merged it now. Åkebråke (talk) 22:35, 3 December 2009 (UTC)

Requested move
Adenomatosis polyposis coli → — Change to the currently approved HUGO  gene name and recommended UniProt  protein name. Boghog (talk) 04:52, 8 July 2010 (UTC)


 * Closed and moved. No dissension. billinghurst  sDrewth  16:55, 16 July 2010 (UTC)

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