Talk:Androgen receptor

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2020 and 14 December 2020. Further details are available on the course page. Student editor(s): LuzAreliContreras.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:17, 17 January 2022 (UTC)

Untitled
There is a Regulatory Domain of the AR-receptor. What's the function of this domain?

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 3 September 2019 and 12 December 2019. Further details are available on the course page. Student editor(s): Yostrerov. Peer reviewers: Annasandberg.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 14:14, 16 January 2022 (UTC)

DHEA interaction with androgen receptor
Currently, this article states:
 * "The androgen receptor [...] is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. "

The dehydroepiandrosterone article states that dehydroepiandrosterone "acts" on the androgen receptor directly. Does this mean that above statement is not correct? --Abdull (talk) 13:40, 21 August 2010 (UTC)
 * "Binding" ≡ "acts". Boghog (talk) 18:28, 21 August 2010 (UTC)
 * The thing is, DHT and T are not the only things which bind to the androgen receptor. Lots of stuff binds to the androgen receptor. This statement about T and DHT needs to be qualified somehow. To give some quick citations;


 * One exception, 16alpha-(3'-bromopropyl)-5alpha-androstane-3alpha,17beta-diol, the only compound bearing a hydroxy group at position 17beta instead of a ketone, showed a strong binding affinity for the androgen receptor (70% at 1 microM) http://www.ncbi.nlm.nih.gov/pubmed/12443041


 * ...is not in itself an agonist steroid on LNCaP (AR(+)) (androgen receptor) cells, and its proliferative activity appears to be mediated by its transformation into A-dione and/or into epi-ADT. http://www.ncbi.nlm.nih.gov/pubmed/18082864


 * Of course, lots of other things bind to AR (see the Androgenics navbox at the end of the article). The statement is already qualified by the adjective "hormones" which rules out androgens that are not endogenous. Boghog (talk) 17:55, 24 June 2013 (UTC)

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Gene location mouse
The location of the AR in the mouse is identified. I thought that this article used to have the location in the human genome as well. 19? No? ( Martin | talk • contribs 00:32, 21 July 2018 (UTC))

Oops. Its on the x chromosome. PSA is on 19, as is TGFβ1 ( Martin | talk • contribs 00:38, 21 July 2018 (UTC))

Editing project
Hello, I am working on a project with my endocrinology class and I have chosen to edit this page. My hope is to further develop this page and make it better. I welcome you to review my edits and provide me constructive criticism and feedback as this is my first time editing on wikipedia. Looking forward to learning as much as I can from this opportunity! Yostrerov (talk) 19:32, 5 October 2019 (UTC)


 * The "Clinical Significance" section seems to cut off abruptly in the middle of a sentence. I'm guessing this was a mistake, but if you're able to flesh this out a bit further it would be appreciated. Lumberjane Lilly (talk) 17:44, 16 December 2020 (UTC)