Talk:Aspartic acid

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): D.Azani. Peer reviewers: Ruwan23.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 14:51, 16 January 2022 (UTC)

Aspartate/Aspartame/etc
How does Aspartate (redirected to Aspartic acid by Wikipedia) compare to Aspartame, the artificial sweetener? The reason I ask is, I found a protein drink that said it contained Aspartate. It had a warning on it for Phenolketonurics that it contains Phenolalynine. I have always associated that notice with Aspartame. Are Aspartate and Aspartame the same thing? Dan 15:16, 28 February 2007 (UTC)


 * Aspartate is the metabolised form of Aspartame 203.97.255.148 (talk) 10:53, 7 June 2008 (UTC)

Hi, the answer should be pretty simple if you read the pages on aspartame, phenylalanine, and phenylketonuria. Aspartame is composed of aspartic acid and phenylalanine. I don't think the discussion page is meant for question-and-answer sessions though. However, if the pages I mentioned previously aren't enough to answer your question on their own, then perhaps they need to be updated. Eddietoran 20:25, 14 November 2007 (UTC)

D/L conformations
I think this page should explain why our bodies use L-aspartic acid for proteinogenesis and D-aspartic acid as a neurotransmitter, and how it converts one to the other. Eddietoran 20:25, 14 November 2007 (UTC)

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&list_uids=11093665&cmd=Retrieve&indexed=google states that "D-Aspartic acid can be enzymatically biotransformed with D-amino acid oxidase and aminotransferase to L-aspartic acid." Eddietoran 20:32, 14 November 2007 (UTC)

Should be aspartate
Aspartate (the deprotonated form) is the physiological form in vivo. Aspartic acid is not a physiological amino acid

Amino acid name
According to the 61st addition of the CRC (page C-112) handbook of Chemistry, Aspartic acid is also referred to as Aminosuccinic acid. This name should probably be added to the IUPAC name as well. I would add it myself, but it would probably be removed if no reason were given. I'm fairly confident that anyone in medicinal chemistry would agree that Aminosuccinic acid and Aspartic acid are two terms describing the same chemical. NatePhysics (talk) 04:59, 29 November 2007 (UTC)
 * I would agree, and believe that one more name should be added - asparaginic acid with references to Medline Plus Encyclopedia. J.D. (talk) 20:21, 4 February 2010 (UTC)
 * What you say jibes with what a quick check reveals. I'm going to be away for a few hours, but I'll back what you've added, so far. (I'll probably make subtle changes.) Try to use the most unimpeachable sources and avoid overly long lists.Novangelis (talk) 20:46, 4 February 2010 (UTC)

IUPAC NAme and Structure
The structure does not match either the CAS Number or the IUPAC Name as there is no stereochemistry in the structure--ChemSpiderMan (talk) 05:12, 19 May 2008 (UTC)

Relationship to Asparagus
Responding to the call for citation needed, need a biochem expert to weigh in. This may be a confusion due to similar name... Asparagusic acid is in asparagus along with other sulfur compounds, but Aspartic acid has no sulfur. "These compounds originate in the asparagus as asparagusic acid and its derivatives, as these are the only sulfur-containing compounds unique to asparagus." - from the Asparagus wiki-entry Hamilton Hall (talk) 16:36, 19 May 2011 (UTC)


 * Asparagine was isolated from asparagus, and aspartic acid was derived from asparagine. I've modified the text and can embellish if you feel it is needed. I'll also take a look at the Asparagus article and see what might be needed.Novangelis (talk) 04:55, 26 July 2011 (UTC)

Why would aspartic acid be sold as a dietary supplement?
This is a request for information that I think should be included in the article. I know other amino acids, e.g., lysine, tryptophane, are sold for specific purposes. What claims are made for aspartic acid and do they have any validity? I'm skeptical about the utility of a non-essential amino acid related to asparagine. Hopefully this request will not be seen as general discussion but petition for article expansion. Thank you all for all that you do. Acarolinensis (talk) 06:33, 8 October 2013 (UTC)

After 3 clinical studies it's not called skepticism any more :D


 * D-AA or L-AA? They're quite different.Bstard12 (talk) 09:56, 1 July 2014 (UTC)

Incorrect Diagrams
I don't know how this went unnoticed, but aren't the diagrams wrong? Amine group should be closer to the carboxyl group. See https://en.wikipedia.org/wiki/File:Amino_Acids.svg for comparison. Aqua3993 (talk) 22:54, 12 February 2015 (UTC)
 * Well, there is no stereochemistry noted so I am not sure if it is a possible notation or not. Just to be sure I've checked the Merck index and picked proper image of L-aspartic acid from commons. But then there is mine question: is the ball-and-stick model correct? --Faskal (talk) 09:37, 2 May 2015 (UTC)
 * Yes, both the ball-and-stick model and the line model are currently of L-aspartic acid.TypingAway (talk) 17:36, 18 May 2015 (UTC)
 * I'm not an expert in chemical modeling (though I have a degree in chemical engineering) but it appears the line diagram and ball-and-stick model are inconsistent. (1) Right end of model should look like the left end, with a double-bonded oxygen and a hydroxy group, not two single-bonded (?) oxygen molecules.  (2) The amino group in the b&s model has three hydrogens but line diagram has two. If others are in agreement, can someone fix this or apply a fix tag to the image? CheMechanical (talk) 21:18, 2 February 2020 (UTC)
 * I switched the 3D image to one that matches numbers of hydrogens on the amino and acid functional groups to match the skeletal diagram. DMacks (talk) 02:45, 3 February 2020 (UTC)
 * Hi, perhaps I missed something, but the skeletal formula drawing has an -NH2 group while the b&s-model and the sf-model have an -NH3 group and one -OH missing... Well Pubmed|D|L|DL just shows the -NH2 variant. --DanSy (talk) 18:17, 22 August 2021 (UTC)
 * But this and this and this is confusing me... I don't think both can be right, or can they? --DanSy (talk) 18:47, 23 August 2021 (UTC)
 * I believe in reality amino acids exist in the zwitterionic form at neutral pH (NH3+ and COO- groups), but since charges are less straightforward to depict in diagrams, they're often depicted in the "netural" form (which is essentially just hypothetical)
 * Droideka30 (talk) 19:11, 3 September 2023 (UTC)

23 Proteinogenic amino acids
Proteinogenic amino acid says there are 22. Unless we can find number 23, perhaps we should stick with 22 for consistentcy.--Wcoole (talk) 00:25, 27 October 2015 (UTC)

Assessment comment
Substituted at 08:26, 29 April 2016 (UTC)

Hi fellow wiki editors, I’m a 3rd year Physiological sciences major at UCLA and I’m going to be editing and adding to this page. I’m new to Wiki editing so if I make a mistake or you as fellow editors see an area that needs additional information and/ or correction, feel free to let me know! -Darien A.

Asparte outline

Introduction: •	Edit and clean up information •	Make the introduction flow better and present background in a clear and concise way •	Diferentiate between aspartate and aspartic acid o	Which form is used in the body o	Its biological relevance •	Mention that our bodies use the D-aspartate confirmation

Discovery: •	Elaborate and verify current posted information o	How it was discovered o	What experiments were used in its discovery Structure: •	Create or locate a useable image demonstrating proper stereochemistry

Metabolism: •	Identify other sources of production •	Fact check currently listed sources •	Write out proper equation (current one does not even include a yield sign)

Other biochemical roles: •	Fact check current information (lacks citations) •	Expand section •	Elaborate •	Write equations of reactions its involved in

Neurotransmitter: •	Elaborate and expand •	Possibly combine this section with another appropriate section

Application and market: •	D-aspartic acid is currently sold by supplement companies as a “testosterone booster” so I’d like to mention that after further research


 * Overall after looking at the talk page I would like to delve deeper into the chemistry and biochemistry of Aspartic acid — Preceding unsigned comment added by D.Azani (talk • contribs) 23:54, 14 February 2017 (UTC)

Aspartate restriction might slow tumor growth
"Denying cancer cells one key amino acid might destroy treatment-resistant tumors LAST UPDATED ON JUNE 28TH, 2018 AT 3:12 PM BY ALEXANDRU MICU E-mail author

A new paper published by researchers from the Laboratory of Metabolic Regulation and Genetics (LMRG) at The Rockefeller University suggests that denying tumors aspartate, a key amino acid whose synthesis hinges on oxygen, could help fight the disease".

--91.155.23.138 (talk) 21:52, 5 August 2018 (UTC)

Not protonated
At the beginning the article states it’s protonated at physiologic pH. I believe this is incorrect. Alexhadded (talk) 00:57, 30 November 2021 (UTC)

pubchem IDs chiral compounds
From Aspartic acid (data page) (to be deleted). Unchecked.
 * 1) &mdash; racemic
 * 2)  &mdash; (D-aspartic acid)
 * 3) &mdash; (L-aspartic acid)
 * 4) &mdash; C(C(C(=O)O)N)[11C](=O)O
 * 5) &mdash; C(C(C(=O)O)[13NH2])C(=O)O


 * -DePiep (talk) 18:32, 1 January 2022 (UTC)