Talk:Bcl-2

Corrected links and some concepts
I removed the paragraph entitled 'Bim' because it seemed to be extraneous info and didn't make a lot of sense. Reference link was also incorrect. Don't think one member of the family should get its own paragraph if no others do. Berry 15:05, 26 April 2006 (UTC)

I changed MMP to MOMP because 1) MOMP is standard in the literature, and 2) MMP is the common abbreviation for the matrix metalloproteinases. I removed PT (permeability transition) because 1) PTP is the more common abbreviation, and 2) it wasn't used anywhere else in the article anyway. EquationDoc 02:00, 9 November 2006 (UTC)

Added links for Bak, Bax, and Bcl-xL in "Function". Deleted "MOM" because this abbreviation is irrelevant in the text. Changed the "believed" mechanism for Bcl-2 regulation of the mitochondrial outer membrane permeabilization for the latest available information regarding the oligomerization of Bax and/or Bak to form a pore in the outer membrane, as well as its blocking by Bcl-2, thus eliminating the vague MOMP concept. Pablufu 11:10, 02 January 2008 (UTC)

At some point I'd like to break this page into two, one describing the Bcl-2 protein, and one describing the Bcl-2 family of proteins (say, Bcl-2_Proteins), thus opening up the possibility for individual pages for each of the 25 or so Bcl-2 proteins. EquationDoc 02:00, 9 November 2006 (UTC)

Format/Editing/Citations
I feel that there are some serious weaknesses in this article-- for example, there is an in-text citation in the paragraph of Bcl-2 and the role it plays in cancer, and the citation is for a study that is almost 20 years old, and extremely obsolete. I feel that this is poor research, and I do not feel comfortable editing it since I have only undergraduate experience with molecular biology. Can someone with more experience in the field take a look at the information and take a try at editing it?--Nakedophelia 22:51, 15 November 2007 (UTC)

The figure showing the domain structure/organization is not correct. Mcl-1 (and probably A1 as well as others) does not possess a BH4 domain (Bcl-2 does however). See the domains contained in Mcl-1 here: http://www.ebi.ac.uk/interpro/ISpy?mode=single&ac=Q07820 —Preceding unsigned comment added by 35.9.6.175 (talk) 14:06, 18 May 2008 (UTC)

Proposed merger
Concerning the proposed merger of Apoptosis regulator proteins, Bcl-2 family into this article:


 * Oppose – the structure of this article is rather unfocused since it concerns both a single gene/protein and a family of related proteins. The article would become even more unfocused if the Pfam_box template were added along side the GNF_Protein_box template that this article already contains.  It would be much cleaner to move most of the material that concerns the family of Bcl-2 proteins to the  Apoptosis regulator proteins, Bcl-2 family article and have this article focus on the specific properties of the Bcl-2 gene/protein.  Boghog (talk) 09:38, 6 June 2010 (UTC)
 * Comment: Sorry, please note that I slightly altered my proposition; I am actually suggesting removing some of the information about the Bcl-2 family from this article now, and placing it in the suggested article instead. I am also in the process of attempting to move the target article to Bcl-2 family.   Giftiger Wunsch    [TALK]  09:42, 6 June 2010 (UTC)
 * Please see Talk:Apoptosis_regulator_proteins,_Bcl-2_family, where I have opened a discussion on the merger.  Giftiger Wunsch    [TALK]  09:47, 6 June 2010 (UTC)
 * Comment – OK, it appears that we agree. I have no objection of moving Apoptosis regulator proteins, Bcl-2 family to Bcl-2 family.  Cheers.  Boghog (talk) 09:48, 6 June 2010 (UTC)

Proposed split (from 2010?)

 * Support – as mentioned above, this article concerns both the specific BCL2 gene/protein and the family of proteins that Bcl-2 belongs to. It would be cleaner to move the material concerning the family of proteins to apoptosis regulator proteins, Bcl-2 family while focus this article on the Bcl-2 gene/protein.  Boghog (talk) 11:00, 6 June 2010 (UTC)


 * I am trying to clean up long standing split tags. I do not have the subject knowlege to deal with this article. If the split is really required then can someone be brave and do it or else can the tag be removed? Op47 (talk) 15:34, 27 December 2011 (UTC)


 * No longer clear what that old split proposal was. - but see below - Rod57 (talk) 14:46, 13 April 2016 (UTC)

Proposed split out of Targeted therapies as BCL-2 inhibitor
I reproposed a split in Dec 2015 (apparently not having seen Op47s comment above) - Since this is an active area (and now the FDA has approved the first) I'll do this split (by moving content to the current redirect) as soon as I get time if no one does first. - Rod57 (talk) 14:46, 13 April 2016 (UTC)
 * In favor. 02:41, 5 May 2016 (UTC)

Normal physiological role?
This article is in a bit of a shocking state! Nothing whatsoever about the normal physiological roles, or the biochemistry and signalling pathways involved in Bcl-2 function? Yes it's important in cancer, but there's much more to this protein. Might start an improvement on this soon. I must be fair and say that this is not just article, most protein articles give undue weight to human pathophysiological conditions, rather than normal physiology or non-human information. Fgf10 (talk) 10:46, 17 December 2012 (UTC)

External links modified
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 * Added archive https://web.archive.org/web/20120718151431/http://www.asianscientist.com:80/tech-pharma/abt-199-bh-3-mimetic-wehi-phase-ia-trial-chronic-lymphocytic-leukemia/ to http://www.asianscientist.com/tech-pharma/abt-199-bh-3-mimetic-wehi-phase-ia-trial-chronic-lymphocytic-leukemia
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