Talk:Benzatropine

comments on article
I ran a Google search for "benztropine" and "First Aid for the Psychiatry Clerkship" and I got four hits--two for wikipedia, and two for some mirror site. Also, whoever put that there should put the source under a "References" section, and a page number in parentheses. And the use of capslock for emphasis is not very encyclopedic.Rmky87 22:58, 16 August 2005 (UTC)

Changes
I changed the article a little bit where it was desperately needed. I am pretty sure that "benztropine" is about 100 times more common than "benzatropine" (the factor of 100 comes from Google searching both terms, Pubmed search is similarly skewed to "benztropine"). Perhaps the title should change to "benztropine." I also mentioned benztropine's dopaminergic activity.Fluoborate 20:55, 15 October 2007 (UTC)

I deleted the acronym DDS. It is not a real, known side effect. Its inclusion as an acronym is most likely a puerile joke by medical students. Hojasmuertas (talk) 01:56, 17 October 2011 (UTC)

Title
Currently, the header reads as follows: "Benztropine (INN), also known as benztropine...". If the title of the article is "Benzatropine", the first word in the header should agree with that. I didn't make the edit, but it's worth talking about this again...as a medical student, I've only ever seen benztropine (without the 'a') in over 20 different reputable medical textbooks. Can we change the title? Prometheus 06:59, 9 May 2012 (UTC)

01-FEB-07 Proper name of medication is "benztropine mesylate". Title of article should be fixed (spelling error) —Preceding unsigned comment added by Fliri (talk • contribs) 21:41, 1 February 2008 (UTC)


 * Wikipedia uses the most common name that the majority use for the titles of its articles. So Benzatropine is listed under that name, with an explanation that it has a longer scientific name in the lede of the article. Hope this helps clarify things for you! ➔ REDVEЯS has changed his plea to guilty 21:46, 1 February 2008 (UTC)

I work in a pharmacy. All of our stock bottles are spelled "benztropine mesylate". All spellings of the product in our labeling and billing system is "benztropine mesylate". All spelling of the product from our pharmacy supplier is "benztropine mesylate".

"Benzatropine mesilate" (and others) may well be commonly accepted variants, but it should be noted that generic version of Ovation Pharmaceutical's Cogentinis benztropine mesylate, according to Ovation itself. —Preceding unsigned comment added by Fliri (talk • contribs) 20:15, 8 February 2008 (UTC)
 * Benzatropine is the proper generic name. It only becomes benzatropine mesylate after it has been combined with a salt in tablet form.-- Metalhead94 TC 14:53, 21 December 2008 (UTC)

@Metalhead94 has made an interesting point, and I'm not sure, but I still think it should be under benztropine, as all text books, pill bottles, and references refer to orally available salt form, and not the free base form. So its an interestng distinction if true, but esoteric, and at its core, essentially misleading and confusing. I think Ill just make the move, and see if anyone flips out and reverses it. After all the article is about the pharm benztropine, not the laboratory free base product. Gizmo.AT (talk) 02:31, 12 May 2012 (UTC) My pill bottle says benztropine mesylate that's the true name it's not benzatropine it's benztropine mesylate,A8v (talk) 21:55, 9 July 2014 (UTC)

Having wasted a lot of time searching for evidence to the contrary, I have concluded that this article title is misspelled. There is no 'a' in benztropine. Counter discussion is welcome, but I am proposing a change from "Benzatropine" to "Benztropine". This is the correct generic name for the molecule, as listed in every international source except this one.

Here is the evidence: Clinical trial of benztropine for Parkinson's from 1956, Published ad for Cogentin from 1960, Published ad for Cogentin from 1972.

Benztropine was first patented and marketed by Merck Sharp and Dohme, so they should know how to spell it. Read any drug monograph for benztropine (Cogentin) printed by MSD.

The claim that "benzatropine" is the International Nonproprietary Name for Cogentin is questionable. If this word appears on some database of INNs, then I would consider it an erroneous entry.

(My quals: I had benztropine prescribed to me after a dystonic reaction in 1981. I graduated in medicine in 1988. I have been prescribing benztropine and spelling it correctly since before the invention of computer-generated prescriptions. I have prescribed it in the last 6 months.) DrX au (talk) 02:02, 28 November 2020 (UTC)

I like benztropine better too, but the official international noproprietary name (INN) is benzatropine. See for example, the most recent list of WHO recommended INNs: https://www.fimea.fi/documents/542809/4011505/INN+lista+ad+83_2020__v.2.pdf/b49c73ce-5f15-cbc2-7792-332ba9f51af3?t=1592238682278 That said, I think, it is allowed to use a non-INN name as a title of a drug Wikipedia article, for example, aspirin. So, I would support renaming the article to benztropine, with no a.

The Sceptical Chymist (talk) 19:11, 28 November 2020 (UTC)


 * That "official" list from Finland appears to not be error-free. If the British Approved Name is benztropine, and the US Adopted Name is benztropine, and the INN has a column in English, then how can it be at odds with the 2 main English-language authorities? And all of the peer-reviewed journal articles since the 1950s? I'll tell you how. INN editors that don't check their facts, or check them using Wikipedia. Errors creep in, and if they remain uncorrected, they propagate into reference documents and eventually become acceptable alternative spellings.


 * I plan to edit this article, and correct the title in good faith. And if I have to engage in a pitched edit battle, so be it. DrX au (talk) 02:24, 1 December 2020 (UTC)
 * I am a member of WHO MedNet INN and can state that the official INN, assigned by WHO in 1959, is, indeed, "benz a tropine". Here is the Third List of Recommended International Non-Proprietary Names for Pharmaceutical Preparations. I will add it to the article as a reference. (I have also checked the internal INN system and can confirm the name remains benzatropine.) Fvasconcellos (t·c) 05:22, 1 December 2020 (UTC)
 * Also: benz a tropine has long been the British Approved Name as well, and is also the compendial name used in the British Pharmacopoeia. The only countries still using "benztropine" as an official name are the U.S. and Japan. Fvasconcellos (t·c) 05:35, 1 December 2020 (UTC)
 * If you read this list of journal articles from the 1950s and 60s, it was spelled “benztropine” in France, Germany, Spain, the UK and the USA. Furthermore, it still is, everywhere else too, despite what was printed in WHO’s INN since 1959. And in every textbook. So I shall leave it at that. DrX au (talk) 10:42, 1 December 2020 (UTC)

Neurotoxicity warning
I am psychiatrist and I have come across a patient who read about the fact the drug has a side effect of psychosis in overdose. He took an overdose to "trip." He was not aware of the fact that in an overdose this drug has neurotoxic side effects. This should be pointed out clearly to prevent this from happening in the future. --202.164.202.87 (talk) 18:10, 5 August 2009 (UTC)

Response: Well the MOA would predict this. Potent anticholinergic. Its effects would probably be similar to Datura and other potent anticholinergic effects. Remember the mad as a hatter, hot as a hare, red as a beet, bloated as a toad, blind as a bat mneumonic device from the med school days. Cant hurt to mention this adverse effect, but until I see contrary evidence, I am going to call this a class effect rather than trying to fear monger people on a potentially useful drug. In general its a bad idea to OD on any psychoactive substance....ha Gizmo.AT (talk) 02:22, 12 May 2012 (UTC)

Habit Formimg?
I don't see anything, positive or negative about this in the article.

Addiction is an issue that should be covered in every article on psychiatric medications. Not that all meds are addcitive, but many are, and the issue should always be addressed.

69.171.160.186 (talk) 21:30, 29 December 2009 (UTC)

It's not... There are no reinforcing effects. Patients often confuse "addictive" and drugs that you need to slowly start and stop. Theres a difference. Sometimes its just best to ease into the tub or ocean rather than to jump right in. Some medications are the same way- ease your body into the change rather than a sudden shift. This is more so with psychoactives, since rapid changes in our brain changes everything about us. Gizmo.AT (talk) 02:28, 12 May 2012 (UTC)

The structure
Did someone sit on the bicyclic unit? —Preceding unsigned comment added by Trueno Peinado (talk • contribs) 06:54, 30 January 2010 (UTC)

Possible treatment for MS
Early in October 2013, a lot of news articles came up mentioning a new study publication where benztropine as indicated as useful in treating MS. Only downside is that the side effects of the drug are pretty much the same as the MS. When does a development like this warrant a mention? Shtanto (talk) 14:00, 24 January 2014 (UTC)