Talk:Beta oxidation

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Untitled
some more information on the activation energy required in starting off the breakdown of the initial energy would be helpful. I think it takes an ATP or something to start it off, but i dont know for sure.

ATP produced
How can 1.5 molecules of ATP be produced Beta_oxidation? Unless I have misunderstood the article, it describes each cycle as producing "14 ATP", broken down into halves of ATP molecules, and as I understand it each FADH2 carries sufficient electrons to produce 2 molecules of ATP while each NADH molecule carries sufficient electrons to produce 3 molecules of ATP. Thus either my incomplete understanding has led me astray, or the article needs clarifying/correcting. Any ideas?

Thanks, Yazza 21:40, 14 November 2006 (UTC)

This looks to be the result of using non-integer versus integer (classic) P/O ratios. Using non-classic or non-integer values for P/O ratio then per 2 electrons transfered to oxygen from FADH2 yields 1.5 ATP. Classic integer values for P/O ratio would yield 2 ATP. Non-integer P/O values have arisen from studies showing that cytochrome c oxidase pumps only 2 protons per 2 electron transfer whereas the classic, integer P/O ratio assumed 4 protons pumped.

Bahrens 23:55, 16 December 2006 (UTC)

Sorry for being trivial, but the diagram is a bit weird. S is usually for Sulphur - clearly here it isn't but people get confused. —Preceding unsigned comment added by 131.111.202.56 (talk) 09:50, 11 April 2010 (UTC)

FA metabolism by brain cells
There is evidence that the brain can use FA as well for its energy metabolism, for example here http://www.ncbi.nlm.nih.gov/pubmed/12843297

Meph636 (talk) 09:25, 20 February 2011 (UTC)

Making it "easier"
I would say the easiest way to explain it, is that beta oxidation breaks it into 2 carbon bits (known as CoA). It can then form acetyl CoA. 129.180.166.53 (talk) 06:17, 10 June 2012 (UTC)

Definition of beta oxidation
"Beta-oxidation is the process by which fatty acids, in the form of glucose molecules, are broken down in the cytosol to generate pyruvate, which enter mitochondria as acetyl-CoA, the entry molecule for the citric acid cycle." 1. fatty acids cannot be in the form of glucose molecules, 2. beta oxidation takes place in mitochondrial matrix, not in cytosol. 3. fatty acids are broken down to Acetyl-CoA, not to pyruvate, and not through pyruvate. 4. acetyl-CoA is already formed in mitochondria, it does not need to enter there. — Preceding unsigned comment added by 161.116.72.200 (talk) 16:28, 9 January 2013 (UTC)

Include a list of organs that are able to use this?
Could be helpful to include. It would be helpful in the context of ketogenesis and ketoacidosis. — Preceding unsigned comment added by 206.12.36.11 (talk) 22:35, 10 July 2013 (UTC)

Hyphenated or not?
The title has "beta oxidation" nonhyphenated, whereas the article has "beta-oxidation" hyphenated. Which one is correct? CielProfond (talk) 20:49, 7 December 2015 (UTC)

Confirmation that short chain fatty acids diffuse across inner membrane of mitochondria
In the part of the article as follows,

"If the fatty acyl-CoA contains a short chain, these short-chain fatty acids can simply diffuse through the inner mitochondrial membrane.[3]"

reference [3] points to http://ajpgi.physiology.org/content/274/3/G518

That reference is about diffusion across the apical membrane of the epithelium in the digestive tract. It refers the diffusion across parts of the cell's membrane and not the mitochondrial parts of the cell. There is no mention in that reference that diffusion occurs across the inner membrane and into the cell's mitochondrial matrix, nor that it receives acyl-CoA that is derived from those SCFAs and therefore generates ATP from that.

The following is one page also refers to the diffusion, though I can not locate the reference to the Guzman and Geelan 1993 study that it refers to.

https://books.google.com.au/books?id=ULsbUPGYaVoC&pg=PA64&lpg=PA64&dq=short+chain+fatty+acids+diffuse+inner+membrane+mitochondria/&source=bl&ots=JDvvIa6T6K&sig=5yvKMv1O7LCjnEQWw2XAY0WxXLA&hl=en&sa=X&ved=0ahUKEwjMr_KTwKHLAhXMEpQKHRgDDO4Q6AEIKzAC#v=onepage&q=short%20chain%20fatty%20acids%20diffuse%20inner%20membrane%20mitochondria%2F&f=false — Preceding unsigned comment added by 202.67.121.45 (talk) 08:23, 2 March 2016 (UTC)

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Energy yield
An anonymous user changed the energy yield numbers in this edit without providing a source. As discussed in the chat above, the non-integer values are more accurate and up-to-date.

In the process, I also reverted User:Snori's wikilink, but I've put it back, because WP:redlinks are good. --Slashme (talk) 12:17, 7 February 2017 (UTC)

Wiki Education assignment: CHEM 300
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