Talk:Carbamazepine

Merge
I noticed that someone added a merge banner to Environmental fate and occurrence of carbamazepine suggesting its merge here. I support the merge. I don't think the topic of "Environmental fate and occurrence of carbamazepine" meets notability guidelines and therefore shouldn't be a standalone article. Much of the content in that article is background information about wastewater treatment and about carbamazepine. It is redundant to content at existing articles. The remaining content that is actually about the environmental fate could be transferred to the existing Environmental fate section already here in carbamazepine. 14:11, 12 December 2014 (UTC)
 * I went ahead and did it. The other article was mostly redundant to Environmental impact of pharmaceuticals and personal care products and the content in that article that was focused on Carbamazepine was based on WP:PRIMARY sources. I think the idea for the content is fine, so I went and found the most recent review I could, created content off that, and then redirected that article to this section. Jytdog (talk) 14:26, 12 December 2014 (UTC)
 * Thank you. Deli nk (talk) 14:33, 12 December 2014 (UTC)

Pharmacogenetics
Hi,

I noticed that someone has re-written the section I wrote/edited on Pharmacogenetics. I am new to Wikipedia, so I apologize if I get any of the Wikipedia etiquette wrong, but I believe I was supposed to start a talk page about this instead of reverting the edits?

A few points to make about the new paragraph:

- The new paragraph has restricted citations to only the US FDA label. While I have no issue with the citing of this label, the paragraph now no longer paints a complete picture of the association between HLA-B *15:02 and carbamazepine. For one thing, the risk in some Asian populations can be up to ~2500 times higher in carriers of the allele, and is often at least above 20; stating that the risk is 10x higher is an understatement. The FDA has been somewhat slow to begin including pharmacogenetic information in their labels, and so while they may be accurate to an extent, often drug labels are not the best source for this type of information.

- An allele is not a form of a protein, it is a form of a gene. Additionally, HLA-B alleles are commonly written in the form *15:02, rather than 1502. Therefore the sentence more accurately should read "...who have a specific version of the HLA-B gene, namely the *15:02 allele..."

- The information from sources such as CPIC and CPDNS have been removed. The implementation of pharmacogenetics in clinical practice is an area of medicine that is relevant to many readers of the page and important in the scope of genetics, so I think these citations are important to leave in the article.

- Information on the other alleles associated with carbamazepine have been removed. These alleles are almost as important as *15:02 - since the *15:02 allele is rare in Caucasians and some Asian populations, any future genetic testing prior to carbamazepine treatment may done for alleles such as *31:01 and *15:11, since they are more common in particular populations.

I understand that there may have been particular Wikipedia-related reasons for why some content was removed - any information about this would be useful so I don't make mistakes on any future pages I contribute to. I also understand that short concise paragraphs are better than rambling ones, but in this case I believe we are now missing some important information about the drug.

Perhaps we can return some information to the page?

Thanks,

Jmbarbarino (talk) 19:19, 5 January 2015 (UTC)
 * hi, the sources you used were primary sources. please see WP:MEDRS. i appreciate you identifying the errors (gene vs protein, and the snp name).  I can fix them or you can. But please don't add back the primary sources though. and to be frank i found the references and wikilinks to CPIC and CPDNS to be WP:PROMO - we are giving information about the drug here. that needs to be the focus. thx Jytdog (talk) 19:25, 5 January 2015 (UTC)


 * Hi, thanks for the information on primary sources - I was not aware of that rule. I will add back information previously deleted through secondary sources if possible. As for the promo, I agree that it may not be appropriate to hyperlink those pages, another thing I did not think about. However, I do disagree with the fact that citing those sources is distracting from focus of the page, since those guidelines represent comprehensive review articles on the link between the drug and potential adverse reactions, information I think may be useful to patients or doctors who may come across the page. Perhaps a compromise might be to not use the names of the sources and say something like "drug dosing guidelines suggest that carbamazepine-naive patients not receive the drug" and then cite the two guidelines? Thanks. Jmbarbarino (talk) 19:38, 5 January 2015 (UTC)
 * we DO NOT give medical advice in wikipedia. please stay very far away from doing that. please see the policy, WP:NOTHOWTO, and see WP:MEDMOS for how we apply NONTHOWTO in medical content.  please do not use primary sources. please keep in mind that WP is an encyclopedia.  we do not seek to be "cutting edge" - we seek to express the medical consensus as clearly as we can, based on the best evidence we can (and what we mean by "best evidence" is described in MEDRS).  thanks. Jytdog (talk) 19:44, 5 January 2015 (UTC)
 * Thanks. Will fix this on other articles I have edited as well. Jmbarbarino (talk) 20:14, 5 January 2015 (UTC)
 * Have updated re. secondary sources and removal of medical advice. Please let me know if further changes are needed. I am not attached to it being its own paragraph. Thanks. Jmbarbarino (talk) 22:11, 5 January 2015 (UTC)
 * thanks! Jytdog (talk) 00:07, 6 January 2015 (UTC)

Mechanism of Action
Made a few changes to the MoA section. Basically I removed the section that said carbamazepine stabilises the inactive state of VG sodium channels. — Preceding unsigned comment added by 213.104.127.138 (talk) 16:56, 18 November 2016 (UTC)