Talk:Cholic acid

Eighty percent?
This article states that "Of the two major bile acids, cholate derivatives represent approximately eighty percent of all bile acids" whereas the bile acid article states "In humans, taurocholic acid and glycocholic acid (derivatives of cholic acid) and taurochenodeoxycholic acid and glycochenodeoxycholic acid (derivatives of chenodeoxycholic acid) represent approximately 80% of all bile salts in bile." These statements cannot both be true.

cholesterol-7-α-hydroxylase regulation
Something seems to be wrong here: "Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why chenodeoxycholic acid, and not cholic acid, can be used to treat gallstones (because decreasing bile acid synthesis would supersaturate the stones even more).[4][5]"

I suspect that it should be cholic acid rather than cholesterol which "does the opposite".

The original contributor(s) of this section should check and clarify this. 115.64.142.162 (talk) 02:32, 15 December 2015 (UTC)