Talk:Chromosome 21

Untitled
Some text in this article was originally taken from http://ghr.nlm.nih.gov/chromosome=21 (public domain)

--- Wikiborg 00:32, 22 February 2006 (UTC)
 * Removing parenthetical comment "(not counting the Y chromosome)". In the page history the author justifies this change by stating that the Y chromosome is actually smaller. This is incorrect.  The current genome build (36.2) lists the Y chromosome as 57.8 million nucleotides and chromosome 21 as 46.9 million nucleotides in length, making it the smallest chromosome as the initial page author indicated.  The chr 21 and Y pages do list the correct sizes though. --- Pat shea
 * PROBLEM: The "Human chromosomes" template table did not show up.
 * DISCUSSION: The table is in the HTML markup.
 * WORKS WITH: Mozilla Firefox 1.0.5 and 2.8.5dev.16.
 * FAILS WITH: Mozilla 1.7.12
 * DIAGNOSTIC: Probable browser error - report to maintainer.

It would be helpful to synch up the Disease names with their related genes. myabe put the gene symbol in parenthesis after the disease? B.K. 16:56, 14 February 2007 (UTC)

Numbering
If chromosome 21 is smaller than chromosome 22, then why are they numbered that way? With the exception of the sex chromosomes, the numbering is otherwise from biggest to smallest, so why aren't 21 and 22 numbered the other way around? Nik42 (talk) 01:12, 27 October 2008 (UTC)

S100B
The S100B gene is also located at the end of chromosome 21, it should be added, but my formatting skills are sub par.

"Clustered organization of S100 genes in human and mouse" 1998 Katrin Ridinger, Evelyn, Felix K. Niggli, Claus W. Heizmann,Beat W. Scha«fer [i]Biochimica et Biophysica Acta[/i] 1448. 254-263

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T20-3VCR29C-C-9&_cdi=4904&_user=8903414&_pii=S0167488998001372&_origin=search&_coverDate=12%2F10%2F1998&_sk=985519997&view=c&wchp=dGLbVzz-zSkzS&md5=32432fa0d3206972481dda3147bfef48&ie=/sdarticle.pdf —Preceding unsigned comment added by 86.15.46.78 (talk) 22:24, 22 November 2010 (UTC)

Smallest Human Chromosome?
Shouldn't it say it's the smallest human autosome? The Y chromosome is smaller. Or are we talking about found in all humans, regardless of sex? — Preceding unsigned comment added by FamAD123 (talk • contribs) 15:42, 12 September 2014 (UTC)
 * FamAD123Yes, I changed it. DennisPietras (talk) 19:51, 3 February 2017 (UTC)

No, the Y chromosome is not smaller in length. Both chromosome 22 and Y are more tightly packed and give the visual appearance when stained and viewed under a microscope of being smaller, which also gives rise to the strange anomaly that chromosome 22 is larger than chromosome 21, despite the apparent scheme of naming them by size. In fact, the Y chromosome is the third smallest human chromosome. I've added in a citation to the National Library of Medicine Human Genome Reference page for chromosome 21 which clearly confirms this. This is also verifiable by comparing the overall chromosome lengths listed for the chromosome Y and 21 Wikipedia pages or the current human genome reference build (https://www.ncbi.nlm.nih.gov/grc/human/data). 73.26.126.59 (talk) 06:33, 31 May 2018 (UTC)patshea