Talk:Germline mutation

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Cjp0001. Peer reviewers: Mrp0007, Jboyle0.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 21:46, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Kristinr.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:20, 16 January 2022 (UTC)

External links modified
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Article Evaluation
The lead of this article provides an insightful understanding for the definition of a germline mutation, while also providing a brief description for each of the article's major components. Although vague in detail, the mention of it's occurrence, causes, clinical implications, and current therapies were present. This allows for viewers, like myself, to be informed of the exact content that is expected to follow. On a side note, this article can still be improved in some areas. There were a few sentences that could have been reworded for a better understanding. For example, the sentence, "This damage is rarely repaired imperfectly, but due to the high rate of germ cell division, can occur frequently." I had to go over this sentence numerous times to understand what was trying to be conveyed. It would have been easier to understand if it was written as, "Because of the high germ cell division rate, the damage occurs frequently, however, this damage is usually perfectly repaired." I would recommend adding more information about how common germline mutations occur and provide statistics to give viewers an idea of how many individuals are affected by such a mutation.

Another improvement that could be made involves creating two different sub-headings underneath the "Clinical Implications" heading. One for the role it plays in genetic diseases and another for the role it plays in different types of cancer. Not only would this help distinguish which category each of the conditions fall under, but it also allows for better organization of the article. In general, more information about how a germline mutation leads to different types of cancer would be a good improvement to this article. This section of the article did not contain enough detailed information and could be expanded upon. Nonetheless, this article possesses content that is up-to-date. While scrolling through the references, I noticed that a good portion of the cited sources were retrieved/published a few years ago. I found myself looking through these recent references that were cited, the latest one retrieved from 2018. Kaira Hosnedl (talk) 22:52, 6 September 2020 (UTC)