Talk:HERG

The name
This sounds fake to me. Ether-a-go-go? Anyone care to explain this ridiculous-sounding name? —Keenan Pepper 10:00, 11 August 2005 (UTC)

No, its quite factual. The hERG channel was identified in Drosophila flies and named so because when they were anaesthetised with ether, their legs started shaking.

bignoter 11:20, August 16, 2005 (UTC)

D. melanogaster gene ether a go-go, abbreviated as eag, encodes a product with voltage-gated potassium channel activity involved in courtship behavior. Mutants shake their legs under ether anesthesia. HERG channel, or KCNH2, is encoded by the eag-related gene, they share some characteristic but are two distinct protein.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=32428

gentile 3:42, September 11, 2005

I am currently adding to this page; I have left some minor grammar errors due to lack of time tonight. While I understand the low priority for ion channels in general, I suspect that because of hERG's central role in virtually all drug discovery programmes for human pharmaceuticals, hERG may be somewhat more important to wikipedia than other channels. Relleh22hctac (talk) 03:09, 2 February 2009 (UTC)

We should fix the name, there is no french accent on the "a". Aytrus (talk) 15:36, 30 May 2010 (UTC)

Side helix
What is the "side helix" mentioned in the 'structure' section? I have never heard of it; does this refer to the alpha helical region in the turret or in the cyclic nucleotide binding domain? I am tempted to delete "side helix". Relleh22hctac (talk) 03:09, 2 February 2009 (UTC)


 * That puzzled me too. After searching PubMed and Google, I cannot find any source to document the use of the term "side helx" in the context of the hERG structure.  Therefore I have deleted it. (BTW: excellent edits Relleh22hctac!).  Cheers.   Boghog2 (talk) 06:42, 2 February 2009 (UTC)


 * Perhaps what was really meant was beta subunit (minK)? That or it was a typo for slide helix. Either way, Boghog2's edits seem an appropriate fix. --Dpryan (talk) 22:27, 2 February 2009 (UTC)

Extra details that need to be added

 * The relationship between hERG and early afterdepolarisations
 * The unusual length of the turret

Suggested subject headings that may ultimately be useful for ion channels
Relleh22hctac (talk) 10:10, 13 February 2009 (UTC)
 * Basic Features (why is it notable)
 * Biological Functions
 * In the Action Potential of Excitable Cells
 * In other cell types
 * Structure
 * Mechanism of Action
 * Gating: How the Channel
 * Selective Permeability
 * Diseases of
 * Location
 * Cells where hERG is found: Expression profile
 * Animals that have hERG
 * Diversity
 * Evolutionary Relationship to other Ion Channels
 * Classification
 * History
 * In Art and Popular Culture (probably not so much for hERG yet)

Image
Use the improved image:. — Preceding unsigned comment added by JVertrees (talk • contribs) 22:37, 19 December 2012 (UTC)

External links modified
Hello fellow Wikipedians,

I have just added archive links to 1 one external link on HERG. Please take a moment to review my edit. If necessary, add after the link to keep me from modifying it. Alternatively, you can add to keep me off the page altogether. I made the following changes:
 * Added archive https://web.archive.org/20141018125540/http://www.ncbi.nlm.nih.gov/pubmed/11927665 to http://www.ncbi.nlm.nih.gov/pubmed/11927665

When you have finished reviewing my changes, please set the checked parameter below to true to let others know.

Cheers.—cyberbot II  Talk to my owner :Online 10:48, 11 January 2016 (UTC)

Structure
Full-length cryo-electron microscopy structures of hERG has been available since 2017: https://doi.org/10.1016/j.cell.2017.03.048 163.1.63.21 (talk) 19:33, 8 February 2023 (UTC)