Talk:Hydroxynorketamine

Legal status
Is hydroxynorketamine a scheduled substance (more technically, are any of the hydroxynorketamines scheduled substances) in any jurisdiction, and if so, what jurisdictions assign it to what schedules? Antediluvian67 (talk) 23:26, 13 February 2017 (UTC)

Regarding "Ketamine and metabolites at the NMDAR"
Drawing from Suzuki K. et al.,(2017), the article states: "a June 2017 study found that (2R,6R)-HNK does in fact block the NMDA receptor, similarly to ketamine.", suggesting that the antidepressant activity of (2R,6R)-HNK may be NMDAR dependent. Significant NMDAR antagonism by this compound was only observed a dosage of 50μM, despite the presence of antidepressant effects at only 10μM. OllyTheBug (talk) 01:35, 6 March 2019 (UTC)