Talk:Hyperimmunoglobulin E syndrome

how much IgE is considered to be hyper ?
i put the 'Expert-verify' tag in the article because the key information of what the normal levels of IgE are in ng/mL or kIU/L is missing. "&gt; 10 times normal" is rather vague when neither this article nor Immunoglobulin E have a referenced value of the normal value or a normal range. Boud (talk) 22:38, 14 August 2008 (UTC)


 * Just a minor issue, but Job was given boils by God, not Satan. At least give credit to the right deity.|||
 * See Job 2.7--it was Satan, but by permission from God. Tarshizzle (talk) 23:07, 1 April 2012 (UTC)

HyperimmunoglobulinEMIA
The article title should read Hyperimmunoglobulinemia E Syndrome, as referenced http://www.ncbi.nlm.nih.gov/pubmed/17458437. Hyperimmunoglobulin is a word with no significance. — Preceding unsigned comment added by Cenayon (talk • contribs) 16:50, 6 October 2015 (UTC) Diddo, this needs to be moved EnviroHealth01 (talk) 21:43, 11 December 2015 (UTC)


 * I do not believe this is incorrect, the general concept of Hyperimmunoglobulinemia means a heightened immunoglobulin response and would not refer to the specific antibody. Hyper-IgE or Hyperimmunoglobulin E is specifically referencing the antibody IgE. It is Hyper as in the levels of this specific antibody. This is in line with the extensive literature on the subject
 * In summary, Hyperimmunoglobulinemia doesn't refer to IgE, IgA or IgM. Hyper-Immunoglobulin E, or Hyper-IgE is the correct reference to this specific class of disorders --Xp fun (talk) 22:05, 4 August 2021 (UTC)

Pathophysiology needs work
Pathopysiology needs work - this is a heterogeneous group of diseases with different genetic causes and biochemical mechanisms. Currently Pathophysiology says: "Abnormal neutrophil chemotaxis due to decreased production of interferon gamma by T lymphocytes is thought to cause the disease.[6][unreliable medical source][non-primary source needed]" Ref 6 is dated 2000; TYK2 gene was the first gene one found, in 2006 (only 2 published cases for that gene). Now 5 genes are known, with different mechanisms and effects. EnviroHealth01 (talk) 21:29, 11 December 2015 (UTC)

Move STAT3 / "Job's Syndrome" specifics to separate page?
Perhaps Autosomal Dominant HIES / HIES-AD / STAT3 / "Job's Syndrome" should be a separate page, which discusses its specific facial/dental/skeletal characteristics, leaving the HIES page to and differentiate between the 5 (or more) genetic plus any acquired causes and discuss any syndromic effects of chronically having IgE >2000. DIDS, PGM3 Deficiency, & Netherton Syndrome all already have specific pages. — Preceding unsigned comment added by EnviroHealth01 (talk • contribs) 21:37, 11 December 2015 (UTC)

Zaria Factor?
I can find no reference to to this, can we revert this change? Xp fun (talk) — Preceding undated comment added 23:13, 21 May 2022 (UTC)